Yearly Archives: 2021

Recently, Pfizer and Moderna have been approved to market a covid mRNA vaccine, which is the first large-scale use of mRNA vaccine. There are many questions about its technology and safety, so we will discuss this new mRNA vaccine. We list 10 questions about this vaccine, we will answer them, and introduce the current situation of vaccine in China.

1. What is an mRNA vaccine?

MRNA vaccine technology started in 1989, which is an artificial preparation of a sequence that can encode protein, optimized by promoter, codon, etc., and can be used as a vaccine to activate humoral and cellular immunity.
With the development of nanocarrier technology, mRNA vaccine encapsulated in nanoparticles can achieve better immune effects, improve vaccine stability, and increase immune pathways (such as intravenous injection).

2. Do mRNA vaccines cause changes in the human genome?

MRNA is medium, the synthesis of protein in our bodies can also exist, mRNA to finish the work in the cytoplasm, by definition will soon been cleaned nucleic acid enzymes in the body, while the “science” reported recently living will coronavirusRNA may reverse transcription to human DNA (see below), but for the man-made mRNA will happen this kind of situation, wish to have doubts and vaccine safety were confirmed after listing, but for security verification is not guarantee for a long time, after all, is the first time.

3. If lipid nanoparticles are added to mRNA vaccine as adjuvants, will these adjuvants have side effects on human body?

As a new adjuvant, lipid nanoparticles adjuvant will have its own standards for research and development and production, and safety tests will also be carried out.
Moreover, adjuvants are not only added to mRNA vaccines, but also need adjuvants to improve the immune effect of other types of vaccines, such as mineral oil adjuvants and aluminum glue adjuvants added to inactivated vaccines.

4. Why is this mRNA vaccine form used in the covid vaccine?

Vaccines come in various forms, including inactivated vaccine, attenuated vaccine, subunit vaccine, DNA vaccine, mRNA vaccine, virus carrier vaccine, etc.
Since the outbreak of the new epidemic, vaccine research has been actively carried out around the world. All the above forms of vaccines are under development and are in different stages.
The rapidity of the mRNA vaccine was partly due to the diligence of the developers and partly due to the inherent advantages of the technology.
MRNA vaccine products can be rapidly designed and optimized based on sequencing sequence and screened in animal experiments and clinical trials.
Therefore, the inherent speed advantage of “bring your own shortcut” indicates that mRNA vaccines will dominate the vaccine market in the future.

5. What are the differences between mRNA covid vaccines currently under development?

At present, the novel coronavirus spiking S protein is basically used as antigen in the development of vaccine, and there are differences only in the aspect of antigen optimization and vaccine platform.

6. Research and development status of covid vaccines in China?

The research and development of China’s covid vaccine is based on five routes, including inactivated vaccine, attenuated influenza vector vaccine, adenovirus vaccine, nucleic acid vaccine and subunit vaccine. The three fastest inactivated vaccines have entered the end of phase III clinical practice. Recently, Sinopill China’s new biological covid inactivated vaccine has been approved for market!

7. Why did the U.S. mRNA covid vaccine go faster than China?

Different vaccine routes have different development cycles and different technical difficulties.
On the one hand, mRNA vaccine products are designed quickly and put into experimental research early.
On the other hand, due to China’s strong epidemic control efforts and good results, the lack of research samples for III clinical trials has also delayed the pace of research.

8. Why don’t the West make inactivated vaccines and go the mRNA route?

The production of inactivated vaccine requires three levels of biosafety protection. In China, P3 laboratory is temporarily transformed into vaccine production, which is not done in the West. Therefore, the route of “bring your own shortcut” mRNA is not chosen for inactivated vaccine.

9. Novel coronavirus consists mainly of 25-28 proteins. Why does a novel coronavirus mRNA vaccine use spiroprotein (S) alone as the target?

S protein is the key protein of virus host cell receptor-mediated virus invasion.
Secondly, S protein exists on the surface of novel coronavirus, which is a good target protein.
Finally, the premise of the selection of vaccine target protein is that the protein must be able to activate the autoimmune response. In addition to antibodies, the complete immune response also requires the co-participation of T killer cells and T helper cells.
Therefore, based on the above three points, the sequence of the vaccine targeted the spiroprotein (S).

10. Which is better, inactivated vaccine or mRNA vaccine?

MRNA vaccines are mostly used in studies of cancer patients, and safety concerns in healthy people have not been completely ruled out.
In this respect, the inactivated vaccine technology is more mature.
Ultimately, a vaccine is judged by its efficacy, that is, which product protects against viral infection, with the ultimate goal of eliminating the virus.
Diversification of vaccine platforms is a good thing, as it reduces risk and improves efficiency.

As expected!
China must be vigilant as WHO reveals’ true face ‘of virus…
In 2020 will be coronavirus come suddenly, not only disrupted the development trend of the global economy, the national airline, economy, trade and so on various aspects have caused a huge obstacles, or even the only superpower in the United States failed to survive, but also become the virus for the first state in the world, as of January 8, the United States will be coronavirus has been more than 22.132 million cases of confirmed cases, and the number of people died as a result, the peak of 374000 in addition to this, confirmed and deaths in the United States still continues to grow, even worse, because the United States give up anywhere to Great Britain, the United States also will face the mutation of large area,
The situation for the United States is even more dire.

News of the mutated virus appeared in Britain last September, but Mr Johnson kept it secret until December last year, and Britain became the target of criticism.
Experts said the most striking feature of the new strain in Britain is that the infection rate is more than seven times that of the previous strain, but it is fortunate that the new strain does not increase the death rate of patients. However, the WHO poured cold water on this relief.

The who director-general, said will be coronavirus influence on human society and beyond that, the most attention to is that a virus variation problem, because the virus is mainly exist in human society, the longer strain change will be more, and the direction or no sure, just because of this uncertainty, will become the thorny issues, let strains in any country temporarily did not prevent the variation method, and currently the only can do is to make the virus prevention and control, precise fall blockade and other restrictions.

It is worth mentioning that although the countries have developed a new vaccine is still effective for mutation, but the who director-general tam kung said, the effectiveness of the new champions league vaccine cannot reach 100%, the effectiveness of the vaccine at the same time is also have a certain limit of time, and once the mutated virus fatality rate change, whether the covid vaccine then also applies the variation virus, is an open question, at present, Canada, Italy, France and other western countries have been mutated virus infections, such as China, Japan also failed to escape.

True, even if the multinational vaccine has entered the testing phase, but still can’t relax to will be coronavirus of alert, and strengthen the virus prevention and control is still the current national priority, although will be coronavirus coming worse in 2021, however, believe that the world unity efforts, will be able to win this battle of virus, hope to be able to put down, all over the world at the same time the virus prevention and control as the only purpose, only successful global disease resistance, countries can restore economic development as soon as possible…

Since the discovery of the mutated covid virus in the UK, the country’s epidemic situation has fallen out of control again. It has broken records many times so far, and the situation is extremely unoptimistic. At the same time, many governments have announced the suspension of flights to and from the United Kingdom, and have banned the entry of British people, hoping to reduce imported cases. Just when countries focused on the field of epidemic prevention, Britain began to do things on its own. According to a report in the Beijing Weekly, British politicians tweeted, please stop saying that the mutant covid virus originated in the UK. It was first discovered in the UK, but it is completely different from the place of origin. What’s more interesting is that the politician named Hermer who posted the article once tweeted many times that the virus originated from China when the covid epidemic just broke out, and said it was a Chinese virus. Hermo himself once publicly dumped China, but now he refuses to admit the mutated virus. Is this a double standard again?

　　 I still remember that when the United Kingdom and other Western countries mentioned the Chinese virus many times, they were warned many times by the Chinese side. The reason is simple. At that time, medical institutions around the world did not determine the origin of the novel coronavirus. Although China was the country where the outbreak occurred for the first time, many news came to light in the later period. Other countries may also have discovered the covid virus earlier, but it was mistaken for influenza or other viruses. On the other hand, Hermo frequently claimed that the covid virus is a Chinese virus in Twitter, and also arrogantly claimed that the outside world calls Indian curry and Korean kimchi. So why can’t the Chinese virus be said? Now the feng shui takes turns, and now the mutant virus was discovered for the first time in the UK, but he refused to admit the British mutant virus, which attracted a lot of criticism from Chinese netizens.

　　 The covid epidemic has not dissipated for a long time, and it is inseparable from the failure of Western countries, especially Western countries headed by the United States. According to the WHO’s description, when the virus appeared, it issued a warning to all countries, but the United States chose to ignore it and did not promptly remind the public to take precautions, so it missed the best stage of epidemic prevention. After being completely out of control, Western countries have not put their main energy into epidemic prevention work, but have been on the international stage, staged the drama of a virus political war, and they are targeting China. They try to push all the responsibility for the virus out of control. On the one hand, China is trying to cover up its own government’s failure to do so, on the other hand, it can also take the opportunity to attack China’s power.

Britain, as one of the allies of the United States, many domestic politicians are pro-American elements, so they also joined the ranks of targeting China. This Helmer is obviously a typical pro-American politician, and every sentence is aimed at discrediting China. To go. But it is a pity that the strategy of the United States and its allies failed. The World Health Organization has repeatedly stood up to call for unity and deny the claims of the Chinese virus. Many countries have criticized the United States for such disruptive practices.

　　 And China’s performance was used to provide the strongest response from the United States and its allies. Under the watchful eyes of other countries, China quickly controlled the whole situation. Even the city of Wuhan where the epidemic first broke out was quickly unblocked. Now that the Chinese people have returned to normal life, all walks of life have resumed work, and the economy is recovering steadily. The WTO also predicts that China is expected to become the only country that will achieve positive economic growth in 2020. Looking at the United States and the United Kingdom, not only has the epidemic situation not stabilized, but it is still in a deteriorating stage. This is a typical manifestation of the wrong position of the center of gravity. It is also that they have taken the blame, but they have suffered the innocent people.

　　 While the situation in the UK was out of control, China chose to ignore the past and reached cooperation with the British medical sector. The two countries also actively discussed emergency plans, hoping to find a way to stabilize the situation for all mankind. This news is great news for the British people. They all know that China has rich experience in fighting the epidemic. With China’s support, they believe that the British epidemic is still promising.

China has gained international recognition through its own efforts, and now its influence continues to increase. Many countries have turned to China for help. The Chinese government has also sent many teams of medical experts to various parts of the world to provide support. At the same time, it has brought supplies, which fully demonstrates Great country style.

The Ministry of Health of Vietnam announced on the 2nd that a case of mutated covid virus infection was found in the country, a Vietnamese citizen who had previously entered the country from the UK. According to reports, the female patient flew from the UK to Vietnam on December 22, 2020. After landing, she was quarantined with other passengers on the plane and was subsequently diagnosed with new coronary pneumonia. A local research institution reported on the 2nd that genetic sequencing showed that the novel coronavirus infected by the patient was consistent with the mutated novel coronavirus reported in the UK recently. Currently, the patient is receiving treatment in the hospital.

One year after the outbreak of the covid epidemic, China has successfully contained the large-scale spread of the virus, but many countries, including the United States, are still deeply involved in the epidemic. The United States once again broke the number of deaths in a single day on December 30 The highest record. The emergence of vaccines has made the world see the light. This is the result of the unremitting efforts of scientists from China, the United States, Britain, France, Russia and other countries. At the moment when vaccines in various countries are unveiled, the pricing of vaccines has also become a hot topic.

The most expensive in the United States, the cheapest in China-free!

From October to November in the United States, the United States was frantically “advertisement” all over the world. At present, there are more than 10 billion vaccine orders in countries around the world, and the total number of vaccine orders from major US companies exceeds 3 billion. Vaccine pricing in various countries has also been announced. The United States has the highest vaccine price, which is between 25-37 US dollars, which is approximately 163-241 yuan equivalent to RMB.

However, recently, problems with vaccines in the United States have been frequently exposed. Medical staff suffered severe allergic reactions after vaccination; vaccine companies urgently destroyed 400,000 vaccines due to production problems. It can be seen from these that there are some problems with vaccines in the United States. Although there are problems with vaccines in the United States, the epidemic in the United States has entered its most serious moment, and the White House has to urgently call out more vaccines. However, the vaccine must be stored in an ultra-low temperature environment and many other restrictions. There are not many people in the United States who really have the opportunity to get the vaccine.

Compared with the price of vaccines in the United States, the price of vaccines in the United Kingdom is particularly “conscience”. The price of vaccines in the UK is only US$4-8 each, which translates to RMB 26-53. However, the UK’s vaccine is only cheap during the epidemic. However, although the British vaccine is cheap, the efficiency of the British vaccine is also very low.

Now the British epidemic has fallen into a new problem. After announcing the emergence of a mutated covid virus, 50 countries have announced the suspension of passenger flights to the United Kingdom, and the United Kingdom has now become an “island” in the world. Although the British government announced free vaccination for all people, it takes time to verify whether the vaccine is effective against variant strains.

The price of Russian vaccines is moderate, about US$10 per dose, which is equivalent to RMB 65. However, the safety of Russian vaccines is open to question. Because the Russian vaccine did not pass the third phase of clinical trials, it was launched in a hurry.

As the pricing of vaccine prices in various countries has been released one after another, when dealing with various affairs, Zeng Yixin, deputy director of the National Health Commission and head of the vaccine research and development team of the Joint Prevention and Control Mechanism of the State Council, said that China’s covid virus vaccine is provided free of charge to all people.

The development of a vaccine is a big project that consumes manpower and material resources. This also includes volunteers’ dedication, multiple trials, and R&D costs, medical staff, etc., to get this inactivated vaccine.

It has to be said that China is a large country with a population of 1.4 billion. China can actually produce vaccines that meet the needs of all people. It can be called a miracle. What is more surprising is that it is also provided for free for all people. This fully reflects the role of a big country. , The responsibility of a great power!

The first case of the mutated virus has been reported in Shanghai, and it is an imported case. The infected person is from the UK, a student from the UK.

The 23-year-old reportedly returned from the UK, causing concern among many parents.
Fear of what happened, really happened!
It’s not even the first day of 2021, which is really worrying.

According to the National Center for Disease Control and Prevention, on January 1, 2021, a mutated virus from the UK appeared in Shanghai, the first of its kind in China.
A 23-year-old female student who flew from the UK to Shanghai was quarantined on December 14 after testing positive for what was initially not thought to be a mutated virus.

Later, when the netizens learned of her behavior, they found it hard to understand. According to her description of the following behaviors, she may have been infected. Let’s see if she is infected or not, she has basic judgment.
Let’s have a look at the student’s dictation.

It is said that before she came back to China, this girl did not wear a mask when running in some parks in the UK, and she must have been paralyzed by herd immunity. It has to be said that herd immunity is very popular abroad, and many people infect each other. When people around her do not think the virus is a problem, everyone will relax.

She also said that she took off her mask when she boarded the plane back to China. Are you angry to hear that?
Why take off your mask on the way back in the UK, feeling infected?
Is this irresponsible for our compatriots back home?

Why is it that people are so relaxed when everyone knows that things have been so bad in The UK?
We should know that now the end of the year in Our country, into the cold winter since, new cases have emerged in succession, has let the parents are worried enough, did not expect now and make such a.

The accident does send a very clear signal that there is an urgent need for vigilance and no room for neglect.
Want to know now the primary and secondary schools have not had a holiday, the students are in the school in class, if the occurrence of this kind of situation in the school, the consequences unimaginable.

Having said that, I have to say that the previous decision to link with the UK was correct and supported by a large number of netizens. It seems that this decision is not wrong and the public’s eyes are still bright.

Luckily for the girl, she came back at the end of the voyage.
But it was unfortunate for the people back home.
It’s important to know that the mutated virus is more risky than the previous one.

When the mask is not taken off, for the sake of self-safety and public safety, it is still necessary to wear the mask in places with heavy traffic.
In recent days, several senior high school students in Heilongjiang Province have tested positive or diagnosed, which has worried their parents and friends. But now that the worst thing has happened, it really makes people feel bad.

At present, each area education branch also made a regulation about having a holiday: insist wrong peak, wrong batch has a holiday, and the requirement is in principle not to leave the place of residence.
In fact, this point is also applicable to other university students, after all, Professor Zhang Wenhong once said: “take precautions, honestly in place, this is the safest!”

Many parents have been concerned about the issue of children’s holiday, from now on, I am afraid it is more looking forward to their children’s holiday.
From the current situation, not to the Spring Festival before and after, it is estimated that there will be a lot of students in the middle and late January back home, some foreign students also want to make a good plan for their whereabouts in advance.

Li now thinks it would be wise for China to stop flights between China and the UK. Look at the case of a 23-year-old British student who tested negative before boarding the plane and tested positive when she returned home.
It was lucky that She returned to China on December 14, and that flights between China and the UK were disrupted later.
If, without decisive melting, it is not known how many British students returned home after Christmas carnival, bringing more than a few unclear transmission chains of the mutant strain.

In any case, Li suggests parents and students pay attention to the following points:

1, winter holiday try not to travel, it is best to stay at home, although it is not as serious as before, but the basic protection is still necessary, especially wearing a mask, wash your hands to continue to adhere to, we have insisted on more than a year, used to the fact that it is good.

2, a little more serious place estimated the holiday time will be longer, so at home to do a more adequate time arrangement, the possibility of online classes is still there, even if there is no online class, students and parents also want to arrange their own homework, go out to make up lessons as far as possible do not consider.

3, overseas students try not to come back, because the current situation is a virus mutation, so come back in the psychological will bring a huge burden to the Chinese, in fact, we have to take good care to protect themselves, others silly we can not follow the stupid.
For the sake of happy freedom, for the sake of their so-called freedom is actually a joke on the lives of others, is to bring others not free.