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Tarpeyo (budesonide) is a medication that has been recently studied for proteinuria treatment in adults with primary immunoglobulin A nephropathy (IgAN). Patients with IgAN produce too many antibodies, which damage the kidneys causing proteinuria. The mechanism of how Tarpeyo works isn’t fully understood, but is suggested to reduce inflammation and improve glomeruli function. Clinical trials show Tarpeyo significantly reduces proteinuria; reducing it by 28% in 9 months compared to placebo. Tarpeyo was also found to be as effective as angiotensin converting enzyme (ACE) inhibitors. Possible side-effects include headaches, nausea, thrush, increased infections, osteoporosis, and glaucoma. Patients must be monitored consistently for kidney function and other health indicators.
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Gamifant is the brand name for the medication with the active ingredient emapalumab-lzsg. It is a prescription drug used in the treatment of a rare and severe condition called hemophagocytic lymphohistiocytosis (HLH) in pediatric and adult patients.
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Saphnelo (anifrolumab) is an FDA-approved medication for the treatment of systemic lupus erythematosus (SLE) in adults. Anifrolumab targets type I interferon receptor, which is overexpressed in many SLE patients, leading to inflammation and organ damage. The medication works by reducing inflammation and disease activity and has been shown to reduce flare rates and corticosteroid use in clinical trials. Anifrolumab is given as an intravenous infusion every four weeks and may have side effects such as nasopharyngitis, upper respiratory tract infections, and infusion reactions. Nonetheless, anifrolumab is a hopeful treatment option for SLE patients who need effective therapies.
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Belumosudil is a new medication approved by the FDA for treating cGVHD in patients who failed previous therapies. By inhibiting the ROCK2 enzyme, belumosudil reduces immune cell activation to decrease cytokines and chemokines that drive inflammation, fibrosis, and tissue damage. Clinical trials on patients with cGVHD demonstrated its efficacy with residual side effects such as hypertension, diarrhea, and fatigue. The medication is administered orally twice a day and requires further testing to determine its efficacy in other immune-mediated conditions.
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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that causes inflammation and tissue damage in multiple organs of the body and requires immunosuppressants and anti-inflammatory medications for treatment. Benlysta (belimumab) is a biologic medication that targets B-lymphocyte stimulator involved in the development of autoantibodies and inflammation in SLE, and is approved for adults and children aged 5 years and above with SLE and adults with active lupus nephritis. Clinical trials have shown that belimumab significantly reduces disease activity and symptoms in patients with SLE and improves renal response in patients with lupus nephritis. Nevertheless, belimumab can cause common side effects such as infections and musculoskeletal symptoms, and may increase the risk of depression and suicide ideation in patients with psychiatric illness.
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Lupkynis (voclosporin) is a medication that, used in combination with other immunosuppressive agents, is effective in treating adults with active lupus nephritis (LN). LN is a serious complication of systemic lupus erythematosus that can cause inflammation and damage to the kidneys. Clinical trials have shown that voclosporin induces complete remission at a higher rate than standard therapy, with a lower rate of treatment failure or worsening of the disease. Although voclosporin has a lower risk of toxicity and drug interactions, side effects like gastrointestinal symptoms and infections have been reported.
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Stelara is the brand name for the medication with the active ingredient ustekinumab. It is a prescription drug used to treat various autoimmune and inflammatory conditions, including psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis.
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Form: Injection – syringe
Strength: 300mg / 2mL
Supply: 1 pack (2 syringes each)
Dupixent is a monoclonal antibody that targets two specific proteins, interleukin-4 (IL-4) and interleukin-13 (IL-13), and has been approved for treatment of moderate-to-severe atopic dermatitis in adults and children aged six and older, as well as moderate-to-severe asthma in patients aged 12 years and above. Dupixent has been proven to significantly reduce the severity and extent of skin lesions, itching, and inflammation in atopic dermatitis patients and significantly reduce the frequency and severity of asthma exacerbations in those with asthma. Dupixent has several advantages over traditional asthma therapies and has a favorable safety profile. The medication offers a new treatment option that targets the underlying pathophysiological mechanisms of chronic inflammatory diseases, leading to better outcomes and improved quality of life.
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CHARACTERISTICS
ACTIVE SUBSTANCE HYALURONIC ACID
FORM 2 ML X 15 MG
MANUFACTURER TAKEDA