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DISEASE INDICATIONS: Risk of cardiovascular events, Hypertriglyceridemia

MANUFACTURER: Amarin Pharma Inc:

USAGE: Oral

MEDICINE APPROVED BY:

European Medical Agency (EMA)

Food and Drug Administration (FDA)

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Vascepa (icosapent ethyl) helps lower triglyceride levels by reducing the production of VLDL cholesterol. It was approved by the FDA in 2012 and is used in high triglyceride level patients.

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DISEASE INDICATIONS: Risk of cardiovascular events, Hypercholesterolemia

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MEDICINE APPROVED BY:

European Medical Agency (EMA)

Food and Drug Administration (FDA)

Health Canada

Pharmaceuticals and Medical Devices Agency (PMDA)

Repatha (evolocumab) is a medication used to lower LDL cholesterol levels. It works by binding to PCSK9 which increases the number of LDL receptors on the liver resulting in a decrease in LDL cholesterol levels. It was approved by the FDA in 2015 and is usually used for patients in high cardiovascular risk or familial hypercholesterolemia.

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DISEASE INDICATIONS: Risk of cardiovascular events

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USAGE: Oral

MEDICINE APPROVED BY:

European Medical Agency (EMA)

Food and Drug Administration (FDA)

Pharmaceuticals and Medical Devices Agency (PMDA)

Verquvo (vericiguat) is a medication used to treat heart failure with reduced ejection fraction (HFrEF) in adult patients. It works by increasing the concentration of cGMP, which relaxes blood vessels and improves blood flow. The FDA approved it in 2021 based on the VICTORIA trial results, which found that it reduced the risk of cardiovascular death and hospitalization for heart failure by 10%.

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USAGE: Oral

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Food and Drug Administration (FDA)

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Orladeyo is a prescription medication used to prevent attacks of hereditary angioedema by reducing the production of bradykinin, which causes swelling and inflammation. It was approved by the FDA in 2020 and is taken orally once daily.

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DISEASE INDICATIONS: Hypercholesterolemia

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USAGE: Oral

MEDICINE APPROVED BY:

European Medical Agency (EMA)

Food and Drug Administration (FDA)

Nexletol (bempedoic acid) is used to lower high levels of LDL cholesterol in the blood. It works by inhibiting an enzyme involved in cholesterol synthesis in the liver. It was approved by the FDA in 2020 and is taken orally once daily.

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DISEASE INDICATIONS: Risk of cardiovascular events

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USAGE: Oral

MEDICINE APPROVED BY:

European Medical Agency (EMA)

Food and Drug Administration (FDA)

Entresto is a medication used to treat congestive heart failure, combining sacubitril and valsartan. It works by boosting peptides that dilate blood vessels and promoting sodium excretion, reducing heart failure’s progression and improving outcomes. Clinical studies show Entresto is effective in improving quality of life, cardiovascular outcomes, exercise tolerance, and symptoms of heart failure.

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