Resof L (Ledipasvir & Sofosbuvir Tablets) is a prescription medication used in the treatment of chronic hepatitis C virus (HCV) infection. It is a combination of two drugs, Ledipasvir and Sofosbuvir, which work together to inhibit the replication of the virus. Resof L is available in tablet form with a strength of Ledipasvir 90 mg and Sofosbuvir 400 mg.
Composition:
Each Resof L tablet contains Ledipasvir and Sofosbuvir as the active ingredients. Ledipasvir belongs to the class of drugs known as NS5A inhibitors, and Sofosbuvir belongs to the class of drugs known as nucleotide analog inhibitors.
Uses:
Resof L is primarily used in the treatment of chronic hepatitis C virus (HCV) infection. It is commonly prescribed to individuals who have not received prior treatment for HCV or have not responded to previous treatment. Resof L is effective against genotype 1, 4, 5, or 6 HCV infections.
HOW TO USE:
Resof L should be taken orally with a glass of water. The tablets can be taken with or without food. The dosage and duration of treatment may vary depending on the individual’s condition, medical history, and their response to the medication. It is essential to follow the instructions of the healthcare provider while taking the medication.
Dosage:
The recommended dosage of Resof L is one tablet once a day. The duration of treatment usually lasts for 12 weeks but may be extended in certain cases. The dosage may be adjusted based on the individual’s condition and lab tests.
Storage Conditions:
Resof L should be stored at room temperature between 20°C to 25°C (68°F to 77°F), away from light and moisture. The tablets should be kept in their original packaging and out of reach of children.
Mechanism of Action:
Ledipasvir and Sofosbuvir, the active ingredients of Resof L, work together to inhibit the replication of the hepatitis C virus. Ledipasvir inhibits the NS5A protein, which is essential for the viral replication process. Sofosbuvir is a nucleotide analog inhibitor that acts as a chain terminator for viral RNA replication.
Precautions:
Before starting treatment with Resof L, it is essential to inform the healthcare provider about any pre-existing medical conditions, including liver disease, kidney disease, and heart problems. It should be used with caution in individuals who are pregnant, breastfeeding, or planning to conceive.
Contraindications:
Resof L is contraindicated in individuals with a known hypersensitivity to any of the active or inactive ingredients in the medication. It is also contraindicated in individuals with severe liver impairment or in combination with other medications that contain Sofosbuvir.
Interactions:
Resof L may interact with other medications used to treat hepatitis C virus. It is important to inform the healthcare provider about all the medications, supplements, and herbal products being taken to avoid potential interactions.
Overdose:
In case of an overdose of Resof L, immediate medical attention should be sought. Symptoms of an overdose may include nausea, vomiting, diarrhea, and abdominal pain.
Side effects:
Common side effects of Resof L may include headache, fatigue, diarrhea, and nausea. Serious side effects may include serious allergic reactions, depression, and liver problems. It is important to report any unusual or severe side effects to the healthcare provider promptly.
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