Velpanat (Velpatasvir & Sofosbuvir) Tablet 28’S is an antiviral medication used in the treatment of chronic hepatitis C virus (HCV) infection. This tablet is a combination of two active ingredients – Velpatasvir 100 mg and Sofosbuvir 400 mg. It works by stopping the growth and spread of HCV in the body, which helps in preventing liver damage, cirrhosis, and liver cancer.
Each tablet of Velpanat contains Velpatasvir 100 mg and Sofosbuvir 400 mg as active ingredients. Apart from these, it also contains some inactive ingredients like magnesium stearate, croscarmellose sodium, microcrystalline cellulose, and lactose monohydrate.
Velpanat is primarily used for the treatment of chronic hepatitis C virus (HCV) infection. It is highly effective in treating all genotypes of HCV (1, 2, 3, 4, 5, 6), both with and without cirrhosis. The medication can be used in adults and children above 12 years of age who are infected with HCV.
Usage and Dosage:
It is recommended to take Velpanat exactly as prescribed by the doctor. The standard dosage of Velpanat is one tablet once a day, with or without food. The tablet should be swallowed whole with a glass of water. The duration of treatment may vary depending on the severity of HCV infection and other medical conditions. It is important to complete the full course of treatment as prescribed by the doctor to get the best results.
Velpanat should be stored in a cool, dry place, away from direct sunlight and moisture. It should be kept out of reach of children and pets. The tablets should not be stored in the bathroom or near the kitchen sink.
Mechanism of Action:
Velpanat contains Velpatasvir and Sofosbuvir, which work by targeting the HCV proteins and blocking their replication in the body, thereby reducing the viral load. Sofosbuvir is an NS5B polymerase inhibitor, while Velpatasvir is an NS5A inhibitor. This combination effectively prevents the HCV virus from multiplying in the body and helps in curing the infection.
Velpanat is contraindicated in patients who are allergic to Velpatasvir, Sofosbuvir, or any of the inactive ingredients present in the tablet. It is also not recommended for patients with severe liver or kidney disease, or those who are pregnant or breastfeeding. Patients should inform their doctor of any medical conditions they may have before starting treatment with Velpanat.
Velpanat may interact with certain medications, including rifampin, carbamazepine, phenytoin, St. John’s wort, and other medications used to treat hepatitis. Patients should inform their doctor about all prescription and non-prescription medications they are currently taking before starting treatment with Velpanat.
Velpanat may cause some side effects in some patients, although not everybody gets them. Some of the common side effects of Velpanat include nausea, headache, fatigue, diarrhea, and insomnia. In rare cases, it may cause serious side effects like liver damage, kidney failure, and anemia. Patients should contact their doctor immediately if they experience any severe allergic reactions or side effects while taking Velpanat.