Kryxana is the brand name for ribociclib, a prescription medication that belongs to a class of drugs known as cyclin-dependent kinase (CDK) inhibitors. It is indicated for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer.
Mechanism of Action:
Kryxana works by inhibiting the activity of cyclin-dependent kinases (CDK) 4 and 6 enzymes, which in turn, prevents tumor cells from growing and dividing. Kryxana, in combination with hormonal therapy, has shown to improve progression-free survival rates in clinical studies.
Kryxana is available in 200mg tablets, and it is usually taken orally once daily. The dosage for Kryxana is based on a patient’s body weight and medical history, and this must be prescribed by a doctor. The recommended dosage for this medication is 600mg, taken orally once daily for 21 consecutive days, followed by a 7-day break where no medication is taken.
Kryxana should be taken with a meal, preferably at the same time each day, and swallowed whole with a glass of water. It should not be chewed, crushed, or broken. Patients taking Kryxana should avoid the consumption of grapefruit, grapefruit juice, and other foods that may interact with the medication. Patients should also avoid the use of hormonal contraceptives while taking Kryxana as it can reduce the effectiveness of the contraceptive.
Kryxana may cause various side effects ranging from mild to severe. Common side effects include a decrease in white blood cell counts, fatigue, nausea, vomiting, diarrhea, and hair loss. Other side effects that may occur less frequently include infections, liver problems, and blood clots. Kryxana may interact with other medications, including herbal supplements and over-the-counter drugs, so it is important to inform the doctor of all the medications being taken. In case of severe side effects, medical attention should be sought immediately.
In conclusion, Kryxana is a drug used in the treatment of advanced or metastatic breast cancer. It works by inhibiting the activity of cyclin-dependent kinases and prevents tumor cells from growing. Kryxana tablets are taken orally once daily with food, as prescribed by a physician. Common side effects include a decrease in white blood cell counts, fatigue, nausea, vomiting, diarrhea, and hair loss. It is important to have medical consultation before taking Kryxana and to avoid interactions with other drugs and certain types of foods.