Dacotin is a brand-name medication containing the active ingredient Oxaliplatin. It is primarily used in the treatment of advanced colon or rectal cancer. It is classified as an antineoplastic agent and is typically administered as an intravenous injection. Dacotin is manufactured by Cipla Limited.
Each Dacotin injection contains 100mg of Oxaliplatin as its active ingredient. The injection also contains other inactive components, such as sodium chloride, mannitol, and water for injection.
Dacotin is primarily used in the treatment of advanced colon or rectal cancer. It is typically used in combination with other chemotherapy medications, such as 5-Fluorouracil and Leucovorin, to increase the chances of successful treatment. Oxaliplatin works by interfering with the DNA replication process of cancer cells, leading to their death and ultimately slowing down disease progression.
Usage and Dosage:
Dacotin is administered as an intravenous injection by a trained healthcare professional. The dosage and duration of treatment depend on several factors, including the patient’s weight, medical history, and response to the medication. Typically, the recommended dosage is 85 mg/m2 administered every two weeks for a total of 12 cycles. Additional doses may be administered as deemed necessary by the treating healthcare provider.
Dacotin injections should be stored at controlled room temperature (between 20°C and 25°C / 68°F and 77°F) in a refrigerator at 2°C to 8°C (36°F to 46°F). It is important to keep this medication out of the reach of children and pets.
Mechanism of Action:
Oxaliplatin, the active ingredient in Dacotin, is classified as a platinum-based chemotherapy drug. It works by binding to the DNA of cancer cells, ultimately leading to their death. Oxaliplatin forms cross-links with the DNA molecules, disrupting its replication and repair mechanisms. This results in the inhibition of cancer cell growth and ultimately slowing down disease progression.
Dacotin is contraindicated in patients with a known hypersensitivity to Oxaliplatin or any other component of the medication. It is also not recommended in patients with severe or uncontrolled infections, severe kidney impairment, or a history of severe allergic reactions. Dacotin should be used with caution in patients with neuropathy or those at risk of developing infections. It is important to discuss any pre-existing medical conditions, medications, or allergies with the treating healthcare provider before starting Dacotin.
Dacotin may interact with certain medications, potentially altering their effectiveness or increasing the risk of adverse effects. It is important to inform the treating healthcare provider about all current medications, including prescription drugs, over-the-counter medications, and herbal supplements. Medications that may interact with Dacotin include other chemotherapy medications, immunosuppressive agents, and vaccines, among others.
Like all medications, Dacotin can cause adverse reactions in some individuals. The most common side effects include nausea, vomiting, diarrhea, fatigue, and neuropathy. Other less common side effects may include fever, rash, and more severe allergic reactions. It is important to promptly report any side effects to the treating healthcare provider for appropriate management.
Dacotin, containing Oxaliplatin 100 mg injection, is a widely used medication for the treatment of advanced colon or rectal cancer. Proper usage, dosage, and adherence to storage conditions are crucial to ensure its effectiveness. Before starting Dacotin, it is important to discuss any pre-existing medical conditions, allergies, or medications with the treating healthcare provider. Regular follow-up appointments and monitoring are essential to manage any potential adverse reactions or interactions.