Maball, a brand name of Rituximab, is a monoclonal antibody used to treat various types of cancer, including non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis. It is available as a 100 mg/10 ml injection in a single-dose vial, and it is administered via intravenous infusion under the supervision of a healthcare professional.
Composition:
Each vial of Maball contains 100 mg of Rituximab, along with other non-active ingredients such as sodium chloride, sodium citrate, and polysorbate 80.
Uses:
Maball is primarily used to treat cancerous and autoimmune conditions. Specifically, its use is indicated in the following conditions:
– Non-Hodgkin’s lymphoma
– Chronic lymphocytic leukemia
– Rheumatoid arthritis
Usage and Dosage:
Maball is administered intravenously in a healthcare setting. The dosage and duration of treatment may vary depending on the patient’s condition, response to treatment, and overall health status. For Non-Hodgkin’s lymphoma and chronic lymphocytic leukemia, Maball is typically given in combination with other chemotherapy drugs. In rheumatoid arthritis, it is given as a single-agent treatment. The recommended dose for lymphoma and leukemia is 375 mg/m² body surface area, and for rheumatoid arthritis, it is 1000 mg given once weekly for four doses.
Storage Conditions:
Maball should be stored in a refrigerator at 2°C to 8°C. Do not freeze or shake the vial. Before use, the solution should be allowed to come to room temperature.
Mechanism of Action:
Maball works by targeting and binding to a specific protein called CD20. This protein is present on the surface of certain cancerous B-cells and autoimmune cells, and its activation leads to cell death via various mechanisms. By binding to this protein, Maball signals the immune system to destroy these cells, leading to decreased tumor growth and improved symptoms in autoimmune conditions.
Contraindications:
Maball is contraindicated in patients with known hypersensitivity to Rituximab or any of its components. It should also not be used in patients with active hepatitis B infection or severe infections.
Interactions:
Maball should not be used in combination with live vaccines due to the risk of vaccine-induced infection. Maball may also interact with other drugs metabolized by the same enzyme system, leading to greater or lesser effects.
Adverse Reactions:
Common adverse reactions associated with Maball include fever, chills, nausea, vomiting, and weakness. Additionally, Maball has been associated with more serious adverse reactions, such as infusion-related reactions, infections, and renal failure. Pre-medication with antihistamines and corticosteroids can help alleviate some of these reactions. Close monitoring of kidney function is also recommended during treatment.
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