Fentanyl 3x 67mcg is a prescription medication used for chronic pain management. The medication contains fentanyl, which is a potent synthetic opioid with analgesic properties. It is formulated as a transdermal patch for continuous delivery of fentanyl over 72 hours.
Fentanyl 3x 67mcg contains 20.1 mg of fentanyl per patch, with a total deliverable dose of 201 mcg per hour.
Fentanyl 3x 67mcg is indicated for the management of chronic pain in patients who require continuous pain relief throughout the day. It is most commonly used for cancer-related pain or other chronic medical conditions that cause ongoing pain.
Usage and Dosage:
Fentanyl 3x 67mcg is administered as a transdermal patch that should be applied to a hairless, intact skin area on the upper torso. The patch should be changed every 3 days. Dosage should be individualized according to the patient’s existing pain medication regimen, pain relief, and side effects.
Fentanyl 3x 67mcg patches should be stored at room temperature between 20°C to 25°C (68°F to 77°F), out of reach of children and pets. The patches should be kept in the protective pouches provided until used. Unused patches should be disposed of properly.
Mechanism of Action:
Fentanyl is a potent μ-opioid receptor agonist that acts by inhibiting the release of neurotransmitters that modulate pain signaling. When applied topically as a patch, the drug is slowly released through the skin over a period of 3 days, maintaining a continuous therapeutic dose and minimizing the risk of acute toxicity.
Fentanyl 3x 67mcg is contraindicated in patients who are hypersensitive to fentanyl or any of the formulation components. It should not be used in patients who are not already receiving opioids for their pain. The medication should be used with caution in patients with respiratory depression, decreased lung function, and hepatic or renal impairment.
Fentanyl 3x 67mcg may interact with other drugs that cause central nervous system depression, such as benzodiazepines, barbiturates, or alcohol. Concurrent use of these drugs may result in increased respiratory depression, sedation, and other adverse effects. Additionally, the use of CYP3A4 inhibitors (such as erythromycin or ketoconazole) may increase fentanyl levels, whereas CYP3A4 inducers (such as rifampin) may decrease fentanyl levels.
Common side effects of Fentanyl 3x 67mcg include constipation, dry mouth, nausea, vomiting, dizziness, and fatigue. More serious side effects, such as respiratory depression, hypotension, and bradycardia, are rare but can be life-threatening. The use of fentanyl patches requires close monitoring of the patient’s clinical status, vital signs, and respiratory function.
In conclusion, Fentanyl 3x 67mcg is a potent medication used for the management of chronic pain. It must be used with caution in patients with respiratory depression or other comorbidities that affect drug metabolism, dosing, or efficacy. Proper storage, administration, and monitoring of the patient are essential to the safe and effective use of fentanyl patches.