ENBREL FLAKON is an injectable medication used for the treatment of various autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, psoriasis, and psoriatic arthritis. It belongs to a class of drugs known as tumor necrosis factor (TNF) inhibitors which work by reducing inflammation in the body.


ENBREL FLAKON contains etanercept as an active ingredient. Each flakon contains 25mg or 50mg of etanercept. It also contains sodium chloride, sodium phosphate, sodium citrate, and mannitol as excipients.


ENBREL FLAKON is used to treat various autoimmune disorders characterized by inflammation in joints, skin, and other organs. Some of the disorders include:

1. Rheumatoid arthritis
2. Ankylosing spondylitis
3. Psoriasis
4. Psoriatic arthritis
5. Juvenile idiopathic arthritis

ENBREL FLAKON is also used to treat other conditions while off-label.

Usage and Dosage:

The dosage and administration of ENBREL FLAKON depend on the specific condition being treated. The medication is administered through injection, and it is usually given once or twice a week, depending on the dose.

For rheumatoid arthritis and psoriatic arthritis, the recommended dose is 50mg administered twice a week for the first three months. After that, the dose can be reduced to 50mg once a week.

For ankylosing spondylitis, the recommended dose is 50mg administered once a week.

For psoriasis, the recommended dose is 50mg administered twice a week for the first three months. After that, the dose can be reduced to 50mg once a week.

For juvenile idiopathic arthritis, the recommended dose is based on the child’s weight.

It is essential to follow the recommended dosage and schedule as prescribed by the physician to achieve best results.

Storage Conditions:

ENBREL FLAKON should be stored in a refrigerator at 2°C to 8°C. The medication should not be frozen or exposed to direct sunlight. Before use, the medication should be brought to room temperature. ENBREL FLAKON should always be kept away from children and pets.

Mechanism of Action:

ENBREL FLAKON works by blocking the action of tumor necrosis factor (TNF) alpha, a substance produced by the body’s immune system that triggers inflammation. In autoimmune diseases, the immune system mistakenly attacks healthy cells and tissues, leading to inflammation and tissue damage. By blocking TNF alpha, ENBREL FLAKON reduces inflammation, relieves symptoms and prevents further tissue damage.


ENBREL FLAKON should not be used in individuals with a known hypersensitivity to the medication or any of its components. ENBREL FLAKON should not be administered to patients with active infections, including tuberculosis, sepsis, and opportunistic infections.


ENBREL FLAKON may interact with other medications, including immunosuppressants such as azathioprine, methotrexate, and cyclosporine. The concomitant use of ENBREL FLAKON with these medications may increase the risk of infections. It is essential to inform the physician of all the medications being taken before starting ENBREL FLAKON.

Side Effects:

ENBREL FLAKON may cause some common side effects, which include:

1. Injection site reactions
2. Headaches
3. Dizziness
4. Nausea
5. Diarrhea
6. Abdominal pain
7. Fatigue

More severe side effects may include:

1. Serious infections such as tuberculosis, sepsis, and pneumonia
2. Allergic reactions such as anaphylaxis
3. Blood disorders such as thrombocytopenia and leukopenia
4. Neurological disorders such as optic neuritis and multiple sclerosis

If any side effects are experienced, it is essential to inform the physician immediately.


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