Leqvio (inclisiran) is a prescription medication used to lower cholesterol levels in adults with primary hypercholesterolemia or mixed dyslipidemia (conditions that cause high levels of fats, including cholesterol, in the blood). It is also used to treat heterozygous familial hypercholesterolemia (a genetic condition that causes high cholesterol).
Leqvio is a small interfering RNA (siRNA) drug. It works by blocking the production of PCSK9, a protein that helps cholesterol to stay in the blood. By blocking the production of PCSK9, Leqvio helps to lower LDL cholesterol levels in the blood.
Leqvio is given as an injection under the skin once or twice a year, after an initial loading dose. The dose is based on the patient’s cholesterol levels and other medical conditions.
How effective is Leqvio?
In clinical studies, Leqvio was shown to be effective at lowering LDL cholesterol levels. In one study, Leqvio reduced LDL cholesterol levels by an average of 52% after 6 months of treatment.
What are the side effects of Leqvio?
The most common side effects of Leqvio are:
- Injection site reactions
- Headache
- Fatigue
- Diarrhea
- Nausea
- Vomiting
- Constipation
- Abdominal pain
- Back pain
- Muscle pain
- Upper respiratory tract infection
Leqvio can also cause more serious side effects, such as:
- Allergic reactions
- Liver problems
- Kidney problems
- Decreased platelet count
Who should not take Leqvio?
Leqvio should not be taken by people who are allergic to inclisiran or any of the other ingredients in Leqvio. It should also not be taken by people with:
- Active liver disease
- Severe kidney disease
- Pregnancy
- Breastfeeding
Important safety information
It is important to tell your doctor about all of the medications you are taking before starting Leqvio. Leqvio can interact with other drugs, such as blood thinners and statins.
Leqvio should be used with caution in people with liver disease, kidney disease, and diabetes.
Leqvio can cause serious side effects, such as allergic reactions and liver problems. It is important to monitor your liver function regularly while taking Leqvio.
If you are considering taking Leqvio, talk to your doctor about the risks and benefits of the medication.
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