Ledifos is a brand name for Ledipasvir and Sofosbuvir tablets manufactured by Hetero Healthcare Ltd. It is a medication used to treat chronic hepatitis C virus (HCV) infection. The active ingredients in the medication are Ledipasvir and Sofosbuvir, which are direct-acting antiviral drugs that target different stages of the HCV replication process.
Uses:
Ledifos is used to treat chronic HCV infection in adults. It is effective for treating all genotypes of HCV infection and is often used as a single-tablet regimen. The medication works by inhibiting the NS5A protein and the NS5B polymerase enzyme, which are essential for the virus to replicate and spread.
HOW TO USE:
Ledifos should be taken as directed by a healthcare professional. Usually, it is taken once a day with or without food. The recommended dose for adults is one tablet (Ledipasvir 90 mg and Sofosbuvir 400 mg) once a day. The duration of treatment may vary depending on the severity of the infection and other factors.
Storage Conditions:
Ledifos should be stored in a cool, dry place at room temperature between 15-30°C (59-86°F). It should be kept out of reach of children and pets.
Mechanism of action:
Ledifos works by inhibiting the NS5A protein and the NS5B polymerase enzyme that are essential for the life cycle of the hepatitis C virus. By inhibiting these enzymes, the medication prevents the virus from replicating and spreading throughout the body. This results in a reduction in the amount of virus in the body and an improvement in liver function.
Precautions:
Before taking Ledifos, individuals should inform their healthcare provider of any medical conditions they have such as liver or kidney disease. It may interact with other medications, so individuals should inform their healthcare provider of all medications and supplements they are currently taking.
Contraindications:
Ledifos should not be taken by individuals who are allergic to Ledipasvir, Sofosbuvir, or any of the other ingredients in the medication. It should not be taken by pregnant or breastfeeding women or by individuals with severe liver or kidney disease.
Drug Interactions:
Ledifos may interact with other medications, including rifampin, St. John’s Wort, and other antiviral medications. Individuals should inform their healthcare provider of all medications they are currently taking to avoid interactions.
Overdose:
An overdose of Ledifos can cause serious side effects such as fatigue, nausea, and abdominal pain. If an individual suspects they have taken too much of this medication, they should seek immediate medical attention.
Side Effects:
Common side effects of Ledifos include fatigue, headache, nausea, and insomnia. It may also cause changes in liver function tests. In rare cases, it can cause severe allergic reactions, so individuals should inform their healthcare provider if they experience any symptoms of an allergy such as rash, itching, or difficulty breathing.
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