Zokinvy (lonafarnib) is a medication used for the treatment of a rare genetic condition called Hutchinson-Gilford Progeria Syndrome (HGPS) and Progeroid Laminopathies with mutations in the lamin A/C gene. HGPS is characterized by accelerated aging and premature death due to heart disease. Zokinvy helps to slow down the progression of the disease and improve the quality of life.
Composition:
Zokinvy contains lonafarnib as the active ingredient. It is available in the form of hard gelatin capsules and each capsule contains 50 mg or 75 mg of lonafarnib.
Manufactured by:
Zokinvy is manufactured by Eiger BioPharmaceuticals, Inc.
Uses:
Zokinvy is used for the treatment of HGPS and Progeroid Laminopathies with mutations in the lamin A/C gene. It helps to slow down the progression of the disease and improve the symptoms associated with it. Zokinvy is not a cure for the disease.
How to Use:
Zokinvy should be taken orally with or without food, twice a day, at the same time every day. The capsules should be swallowed whole with water, without crushing or opening them. It is essential to follow the dosage and dosing schedule provided by your healthcare provider.
Dosage:
The recommended dose of Zokinvy is based on the patient’s weight. The dose may be adjusted by your healthcare provider based on your response to treatment and tolerability. The recommended starting dose is 150 mg per day (75 mg twice a day).
Storage Conditions:
Zokinvy should be stored at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets. Do not use the medication if the packaging is damaged or if the expiry date has passed.
Mechanism of Action:
Zokinvy inhibits the activity of an enzyme called farnesyltransferase, which is involved in the production of a protein called progerin. Progerin is a defective protein that accumulates in the cells of individuals with HGPS and Progeroid Laminopathies, leading to accelerated aging and premature death. By inhibiting the production of progerin, Zokinvy helps to slow down the progression of the disease.
Precautions:
– Inform your healthcare provider about any underlying medical conditions, allergies, or medications you are currently taking.
– Regular check-ups and laboratory tests may be required to monitor your progress and check for any side effects.
– Use caution while driving or operating heavy machinery as Zokinvy may cause dizziness or blurred vision.
Contraindications:
Zokinvy is contraindicated in individuals who are allergic to lonafarnib or any other components of the medication.
Interactions:
Zokinvy may interact with certain medications, including CYP3A4 inhibitors and inducers. Inform your doctor about all the medications you are taking to avoid any potential drug interactions.
Overdose:
In case of an overdose, seek immediate medical attention or contact the poison control center. There is limited information available about the effects of an overdose with Zokinvy.
Side Effects:
Common side effects of Zokinvy may include:
– Diarrhea
– Nausea
– Vomiting
– Abdominal pain
– Headache
– Fatigue
Contact your doctor if you experience any severe or persistent side effects.
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