Isturisa (osilodrostat) is a medication used for the treatment of adults with Cushing’s disease who cannot undergo pituitary surgery or have undergone the surgery but continue to have elevated cortisol levels. It works by inhibiting an enzyme involved in the production of cortisol, a hormone that is normally produced by the adrenal glands.
Composition:
Isturisa contains osilodrostat as the active ingredient. It is available in the form of tablets and each tablet contains 1 mg, 5 mg or 10 mg of osilodrostat.
Manufactured by:
Isturisa is manufactured by Novartis Pharmaceuticals Corporation.
Uses:
Isturisa is used for the treatment of Cushing’s disease, a rare condition caused by the excess production of cortisol by the adrenal glands. It helps to reduce the production of cortisol and improves the symptoms associated with the disease.
How to Use:
Isturisa should be taken orally with or without food, once a day, at the same time every day. The tablets should be swallowed whole with water, without crushing or chewing them. It is essential to follow the dosage and dosing schedule provided by your healthcare provider.
Dosage:
The recommended starting dose of Isturisa is 2 mg taken once daily. The dose may be gradually increased by 1 to 2 mg at weekly intervals until the required dose is achieved. The maximum recommended dose of Isturisa is 30 mg per day. The dosage may vary depending on the patient’s response to treatment and medical condition.
Storage Conditions:
Isturisa should be stored at room temperature, away from direct sunlight and moisture. Keep it out of reach of children and pets. Do not use the medication if the packaging is damaged or if the expiry date has passed.
Mechanism of Action:
Isturisa acts by inhibiting the 11-beta-hydroxylase enzyme, which is involved in the production of cortisol. This helps to reduce the production of cortisol and improve the symptoms associated with Cushing’s disease.
Precautions:
– Inform your healthcare provider about any underlying medical conditions, allergies, or medications you are currently taking.
– Regular check-ups and laboratory tests may be required to monitor your progress and check for any side effects.
– Use caution while driving or operating heavy machinery as Isturisa may cause dizziness.
Contraindications:
Isturisa is contraindicated in individuals who are allergic to osilodrostat or any other components of the medication.
Interactions:
Isturisa may interact with certain medications, including strong CYP3A4 inhibitors and inducers. Inform your doctor about all the medications you are taking to avoid any potential drug interactions.
Overdose:
In case of an overdose, seek immediate medical attention or contact the poison control center. Symptoms of overdose may include nausea, vomiting, headache, dizziness, and low blood pressure.
Side Effects:
Common side effects of Isturisa may include:
– Nausea
– Headache
– Fatigue
– Abdominal pain
– Diarrhea
– Hypertension
Contact your doctor if you experience any severe or persistent side effects.
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