Buy ZENEGRA-50 Online

Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
Formula: C22H30N6O4S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

Product Overview:

ZENEGRA-50 is a pharmaceutical product containing Sildenafil Citrate as its active ingredient. Each tablet is formulated with 50 mg of Sildenafil, a potent and selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). This medication is specifically designed to treat erectile dysfunction (ED) in men, helping them achieve and maintain an erection sufficient for satisfactory sexual performance. Manufactured by Alkem Laboratories, ZENEGRA-50 comes in a pack of four tablets, making it convenient and easy to use.

Active Ingredient:

The active ingredient in ZENEGRA-50 is Sildenafil Citrate, a well-known medication used primarily for treating erectile dysfunction. Sildenafil Citrate works by increasing blood flow to the penis during sexual stimulation, leading to an erection. It does this by inhibiting the PDE5 enzyme, which regulates blood flow in the penis. By blocking this enzyme, Sildenafil enhances the natural erectile response to sexual stimulation, thus helping men with ED to achieve and maintain an erection.

Mechanism of Action:

Sildenafil Citrate, the active ingredient in ZENEGRA-50, belongs to a class of drugs known as PDE5 inhibitors. PDE5 is an enzyme found in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis. When a man is sexually aroused, nitric oxide (NO) is released in the corpus cavernosum. Nitric oxide activates an enzyme called guanylate cyclase, which increases the levels of cyclic guanosine monophosphate (cGMP). The cGMP causes relaxation of smooth muscles and increased blood flow to the penis, resulting in an erection.

PDE5 breaks down cGMP, which can prevent an erection from occurring or cause it to end prematurely. By inhibiting PDE5, Sildenafil Citrate allows cGMP to accumulate, leading to prolonged smooth muscle relaxation and increased blood flow into the penis, thereby enhancing erectile function.

Indications:

ZENEGRA-50 is indicated for the treatment of erectile dysfunction in men. Erectile dysfunction is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. This medication is intended for use only in men and should not be taken by women or children.

Dosage and Administration:

The recommended starting dose of ZENEGRA-50 is one tablet (50 mg) taken approximately one hour before sexual activity. However, ZENEGRA-50 can be taken anywhere from 30 minutes to four hours before sexual activity. The maximum recommended dosing frequency is once per day. The dose can be adjusted based on efficacy and tolerability. For some men, a higher dose of 100 mg may be necessary, while others may find a lower dose of 25 mg sufficient. It is important to follow a healthcare provider’s instructions regarding the appropriate dosage.

ZENEGRA-50 should be swallowed whole with water. It can be taken with or without food; however, taking it with a high-fat meal may reduce the rate of absorption and delay its effects.

Contraindications:

ZENEGRA-50 is contraindicated in individuals with a known hypersensitivity to Sildenafil or any of the components of the tablet. It should not be used by men who are advised against sexual activity due to cardiovascular risk factors. Additionally, ZENEGRA-50 should not be taken with nitrates (commonly prescribed for chest pain) or nitric oxide donors, as this can lead to a dangerous drop in blood pressure.

Precautions and Warnings:

• Cardiovascular Risk: Patients with cardiovascular disease should consult their healthcare provider before using ZENEGRA-50. The use of Sildenafil can lead to serious cardiovascular events, such as myocardial infarction or stroke, particularly in individuals with pre-existing heart conditions.
• Interaction with Other Medications: ZENEGRA-50 may interact with certain medications, including but not limited to nitrates, alpha-blockers, antihypertensives, and other PDE5 inhibitors. Combining these drugs with Sildenafil can cause significant drops in blood pressure or other adverse effects.
• Priapism: Prolonged erection greater than four hours (priapism) is a rare but serious side effect of ZENEGRA-50. If an erection persists longer than four hours, immediate medical assistance is required to prevent permanent damage to the penis.
• Vision Impairment: Sudden vision loss in one or both eyes may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition that has been reported with the use of PDE5 inhibitors like Sildenafil. Patients experiencing sudden vision loss should stop taking ZENEGRA-50 and seek medical attention promptly.

Potential Side Effects:

Common side effects of ZENEGRA-50 include:

• Headache: This is the most frequently reported side effect, experienced by some men due to the dilation of blood vessels caused by Sildenafil.
• Flushing: Some men may experience redness or a warm sensation in the face or neck.
• Dyspepsia: Indigestion or an upset stomach can occur in some individuals.
• Nasal Congestion: A stuffy nose is another possible side effect.
• Dizziness: Some users may feel dizzy or lightheaded, especially when standing up quickly.

Less common but more serious side effects include:

• Chest Pain: If chest pain occurs during or after sexual activity, patients should refrain from further activity and seek immediate medical help.
• Severe Allergic Reactions: Symptoms may include rash, itching, swelling of the face or tongue, or difficulty breathing. Immediate medical attention is necessary if these symptoms occur.
• Hearing Loss: Sudden decrease or loss of hearing has been reported rarely, and in such cases, the medication should be discontinued, and a healthcare professional should be consulted.

Drug Interactions:

ZENEGRA-50 can interact with various medications, which can alter its effectiveness or increase the risk of side effects. It is important to inform the healthcare provider of all medications being taken, including:

• Nitrates: Co-administration with nitrates is contraindicated due to the risk of a significant drop in blood pressure.
• Alpha-blockers: These medications, used for high blood pressure or prostate conditions, can lead to hypotension when taken with ZENEGRA-50.
• CYP3A4 Inhibitors: Drugs like ketoconazole, erythromycin, or protease inhibitors can increase Sildenafil levels in the blood, leading to potential side effects.
• Other PDE5 Inhibitors: Taking other medications for erectile dysfunction concurrently with ZENEGRA-50 can increase the risk of side effects.

Storage Instructions:

ZENEGRA-50 should be stored at room temperature, between 20-25°C (68-77°F). It should be kept in its original packaging, away from moisture and heat, and out of reach of children and pets. The tablets should not be used after the expiration date indicated on the packaging.

Conclusion:

ZENEGRA-50 (Sildenafil Tablets IP) offers an effective solution for men dealing with erectile dysfunction. With its proven efficacy and well-established safety profile, ZENEGRA-50 can help men regain confidence and improve their sexual health. However, it is important to use this medication under the guidance of a healthcare professional to ensure safe and effective treatment. By adhering to the recommended dosage and being aware of potential interactions and side effects, users can optimize their experience with ZENEGRA-50 and enjoy a fulfilling sex life.