Chemical name: (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine
Formula: C21H23NO
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
VRILIGY-60
Vriligy-60 (Dapoxetine, Generic Priligy) is manufactured by Centurion Laboratories, India. Each tablet contains 60mg of as its active ingredient. Dapoxetine is a selective serotonin reuptake inhibitor that is used to help men aged 18 to 64 years of age experiencing premature ejaculation. Premature ejaculation is characterized by the occurrence of ejaculation with minimal sexual stimulation before, during or shortly after penetration before a man desires for it to occur. This drug is also helpful in men experiencing distress as a result of premature ejaculation and men with poor control over ejaculation.
This drug works by increasing the serotonin activity in the nervous system. Serotonin is a neurotransmitter that sends messages between nerve cells and has different body functions. It is also responsible in sending nerve messages resulting in ejaculation. Increased activity of serotonin aids in the increase in time before ejaculation occurs and helps improve control over ejaculation.
Dosage:
A dose will differ from one man to another as it will greatly depend on the age, response to treatment and other medical factors. For men aged 18 to 64 years, the recommended initial dose of Vriligy-60 is 30mg. A physician may increase the dose to 60mg if the initial dose is not quite effective for the patient as long as side effects are tolerable. A tablet is taken by mouth, swallowed whole with a glassful of water without regard for food. It should be taken 1 to 3 hours prior to sexual activity to help men last longer before reaching climax.
Vriligy-60 is not intended to be taken on a daily basis as a maintenance treatment. It should only be taken as needed, when a sexual activity is expected. Not more than 1 tablet must be taken within a 24-hour period.
Contraindications:
Vriligy-60 must not be taken by those allergic to the active ingredient Dapoxetine, and to all inactive ingredient of the tablet. This drug is also contraindicated patients with the following medical conditions:
Heart problems such as heart failure, heart block, heart valve problems, angina
History of heart attack
History of fainting
History of bipolar disorder, mania or hypomania, severe depression
Psychiatric illness like schizophrenia
Uncontrolled epilepsy
Severe kidney problems
Moderate to severe liver problem
Vriligy-60 is also contraindicated in concomitant treatment with the following drugs:
Monoamine oxidase inhibitors
Thioridazine
Selective serotonin reuptake inhibitors
Serotonin-norepinephrine reuptake inhibitors
Tricyclic antidepressants
Other drugs and herbal products with serotonergic effects
CYP3A4 inhibitors
Vriligy-60 must not be used by women, children and adolescents below 18 years of age.
Side effects:
Vriligy-60 can also cause side effects, just like any other medication. But each patient taking the drug will have varying side effect experiences. Some patients can tolerate the drug well and do not experience any side effect, while others may have a different experience. The most common side effects of the drug include dizziness, drowsiness, and headache.
Healthcare professionals must be notified of any of the following side effects associated with Vriligy-60 use:
Anxiety
Insomnia
Reduced libido
Tiredness
Ringing in the ears
Blurring of vision
Congestion of sinuses
Gastrointestinal disturbances such as diarrhea, vomiting, constipation, abdominal pain, indigestion, flatulence
Excessive sweating
Flushing
Blood pressure increase
Vriligy-60 also rarely causes the following side effects:
mood changes
confusion
nightmares
slow or fast heartbeat
teeth grinding
Notify a healthcare professional for any of the above symptoms. Use of Vriligy-60 must be stopped and emergency medical help is needed for signs of serious allergic reaction such as hives, trouble breathing, and swelling of face, lips, tongue or thoat.
Warnings and Precautions
A healthcare professional must be notified of all current medical conditions, all personal or family medical history and all medications being taken and have recently stopped taking, to determine the safe use of Vriligy-60. This drug must be used in caution by patients with the following health conditions:
mild to moderate kidney problem
mild liver problem
history of low blood pressure
history of bleeding disorders
raised eye pressure or risk of closed-angle glaucoma
Caution is advised to dehydrated patients due to prolonged diarrhea, vomiting or excessive sweating, as it may increase the risk of fainting. Those taking drugs that affect clotting factor of blood such as anticoagulants, NSAIDs or acetylsalicylic acid, must use this drug with caution because bleeding abnormality has been associated with Vriligy-60. Orthostatic hypotension has also been reported with Vriligy-60 use – orthostatic test must be done prior to Vriligy-60 use. Caution is advised to patients taking drugs that cause vasodilation such as nitrates and PDE5 inhibitors. Recreational drugs with serotonergic activity must not be used with Vriligy-60 as it may cause potentially serious reactions like serotonin syndrome, arrhythmia, and hyperthermia. Recreational drugs with sedative properties may increase the risk of somnolence and dizziness. Caution is also advised when driving and using hazardous machineries as the drug can cause dizziness, syncope, blurring of vision, somnolence and disturbance in attention.
Drinking alcohol while taking Vriligy-60 must be avoided for it can increase the risk of side effects such as dizziness and drowsiness. It can increase adverse effects such as fainting or syncope, hence increasing risk to injury.
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