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What is Truxima (rituximab)?

Truxima (rituximab) is a monoclonal antibody that targets CD20 molecules found on B-lymphocytes, which are involved in various immune system dysfunctions. It is indicated for primary diseases such as follicular and diffuse large B-cell non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, severe active rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis.

Truxima is the first rituximab biosimilar that can be used for approved indications alone or in combination with other therapies in the United States and the European Union.

How does Truxima (rituximab) work?

Truxima contains the active ingredient rituximab, which is an antibody working against the CD20 protein present on the surface of B-cells. Abnormalities in the immune system resulting from dysfunctions of B-lymphocytes can cause several diseases. These include non-Hodgkin’s lymphoma (NHL), rheumatoid arthritis, and granulomatosis with polyangiitis. By binding to CD20, rituximab initiates cell death, which stops B-cells from causing these severe pathologies.

Where has Truxima (rituximab) been approved?

Truxima (rituximab) has been approved in various countries, including the United States, the European Union, Australia, Canada, and New Zealand.

How is Truxima (rituximab) administered?

The dosage and administration of Truxima (rituximab) vary depending on indications and patient condition. Therefore, it is essential to consult a physician for personalized dosing information. The official prescribing information contains complete details of dosage and administration information.

Are there any known side effects or adverse reactions of Truxima (rituximab)?

Common side effects of Truxima (rituximab) can include fever, infusion reactions, chills, asthenia, headache, and infections. Serious adverse reactions listed in the prescribing information include tumour lysis syndrome, cytokine release, progressive multifocal leukoencephalopathy, angina pectoris, cardiac arrhythmias, and severe skin reactions. Pregnant and breastfeeding women are advised to avoid using Truxima as it may have fatal effects on the fetus. The official prescribing information provides a comprehensive list of side effects and adverse reactions.