What is Jyseleca (filgotinib) used for?
Jyseleca (filgotinib) is a JAK1 inhibitor prescribed for adults with moderate to severe active rheumatoid arthritis (RA) who do not respond well to other anti-rheumatic medications. It is available as 200mg tablets and can be used alone (monotherapy) or with methotrexate (MTX).
How does Jyseleca (filgotinib) work?
In RA, the immune system starts attacking the body’s healthy tissue, which causes inflammation and joint pain. Filgotinib is an active substance that blocks JAK1 enzymes that play a vital role in inflammation associated with rheumatoid arthritis. By blocking JAK1, Jyseleca helps ease the inflammation linked with RA, thus reducing symptoms such as swelling, stiffness, and tiredness in the joints.
Where has Jyseleca (filgotinib) been approved?
Jyseleca (filgotinib) has been approved by the European Medicines Agency (EMA) and Pharmaceuticals and Medical Devices Agency (PMDA) for the acute treatment of migraine in adults. It is also being tested for the treatment of various inflammatory diseases such as Crohn’s disease, psoriatic arthritis, ankylosing spondylitis, and Ulcerative colitis. Although the US Food and Drug Administration (FDA) has previously raised concerns about testicular toxicity associated with high doses of filgotinib, the drug has not been approved for RA treatment in the US.
How is Jyseleca (filgotinib) administered?
The standard dose for Jyseleca (filgotinib) is 200mg of the tablet administered orally once daily. The treatment may be halted if the levels of certain white blood cells or haemoglobin fall below a predetermined level. Patients should start Jyseleca (filgotinib), considering the guidance of an experienced doctor.
Are there any side effects or adverse reactions related to Jyseleca (filgotinib)?
Jyseleca (filgotinib) may cause common side effects such as dizziness, nausea, and upper respiratory tract infections in some patients. Serious side effects may include an increased risk of serious infections or testicular toxicity associated with high doses. Women who can conceive must use effective contraception 1 week before the start of treatment. Pregnant and breastfeeding women are advised to avoid using Jyseleca (filgotinib). The official prescribing information provides a comprehensive list of side effects and adverse reactions.
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