Instgra, also known by its generic name Dolutegravir, is an antiretroviral medication used to treat HIV-1 infection in adults and children weighing at least 30 kg. It is marketed by Emcure Pharmaceuticals Ltd. in the form of 50 mg tablets packed in a pack of 30 tablets. It works by inhibiting the HIV integrase enzyme, thereby preventing the replication of the virus.

– Instgra is used as a part of combination therapy to treat HIV-1 infection in adults and children.
– It is prescribed for patients who are already on antiretroviral treatment and require a change of medication due to treatment failure or drug resistance.
– It is also used for the prevention of HIV-1 infection in people who are at high risk of acquiring the virus.

How to Use:
– Instgra should be taken as directed by the healthcare professional who prescribed it.
– It is usually taken once daily with or without food.
– The tablet should be swallowed whole and not crushed or chewed.
– It is important to follow the dosage instructions and not miss any doses to ensure the effectiveness of treatment.

Storage Conditions:
– Instgra should be stored at room temperature between 15-25°C.
– It should be kept in its original packaging to protect it from light and moisture.
– Keep out of reach of children and pets.

Mechanism of Action:
– Instgra works by inhibiting the integrase enzyme, which is responsible for integrating the viral DNA into the host cell DNA.
– This prevents the virus from replicating and reduces the viral load in the patient’s body.
– Instgra has a high binding affinity for integrase and is very effective in suppressing the virus.

– Instgra should not be used in patients who are allergic to it or any of its components.
– It should be used with caution in patients with a history of liver disease, renal impairment, or bone marrow suppression.
– It should be used with caution in patients taking other medications that may interact with it.
– Patients should be regularly monitored for signs of liver or kidney damage.

– Instgra should not be used in patients with severe liver disease.
– It should not be used in pregnant women without consulting a healthcare professional.
– It should not be used in patients taking dofetilide, rifampin, or carbamazepine.

Drug Interactions:
– Instgra may interact with other medications, such as rifampin, carbamazepine, antacids, and iron supplements, among others.
– Healthcare professionals should be aware of the potential drug interactions and adjust the dosage accordingly.

– In case of an overdose, seek medical attention immediately.
– Symptoms of an overdose may include nausea, vomiting, and dizziness.

Side Effects:
– The most common side effects of Instgra include headache, diarrhea, nausea, and insomnia.
– Other side effects may include rash, fever, abdominal pain, and liver or kidney damage.
– Patients should report any side effects to their healthcare professional.


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