Xofluza (baloxavir marboxil) is a medication indicated for the treatment of acute uncomplicated influenza in patients 12 years of age and older who have been symptomatic for no more than 48 hours. Xofluza is an antiviral drug that works by inhibiting an enzyme called cap-dependent endonuclease, which plays a crucial role in the replication of the influenza virus.
Xofluza is different from other influenza treatments, such as Tamiflu (oseltamivir), because it works by blocking the virus’s ability to replicate. Tamiflu, on the other hand, works by inhibiting an enzyme called neuraminidase, which is essential for viral release. By blocking the release of the virus, Tamiflu can prevent the spread of the virus to other cells but Xofluza can inhibit and stop further replication.
Xofluza is administered orally and is taken as a single dose. The recommended dose for Xofluza is determined by the patient’s weight and varies depending on their weight. The medication is taken orally as one tablet by dissolving it in water.
Clinical studies have demonstrated that Xofluza is effective in reducing the duration of influenza symptoms by approximately one day and reducing viral shedding, which is the period during which an infected person can transmit the virus to others. Patients who took a single dose of Xofluza had a faster recovery from influenza compared to those who did not take the medication.
Xofluza has been shown to be effective against various strains of the influenza virus, including H1N1, H3N2, and influenza B. The medication is well-tolerated, with the most common side effects being diarrhea, bronchitis, nausea, and headache. Xofluza is generally safe but can cause severe allergic reactions in rare cases.
Xofluza is not recommended for patients with severe influenza who require hospitalization or for patients who have been symptomatic for more than 48 hours. The medication is also not recommended for patients who are pregnant or breastfeeding, as the safety of the drug in these populations has not been established.
In conclusion, Xofluza (baloxavir marboxil) is a medication indicated for the treatment of acute uncomplicated influenza in patients 12 years of age and older who have been symptomatic for no more than 48 hours. Xofluza works by inhibiting an enzyme crucial for the replication of the influenza virus, making it different from other influenza treatments. The medication is administered orally as a single dose and is generally well-tolerated, with diarrhea, bronchitis, nausea, and headache being the most common side effects. Xofluza is not recommended for patients with severe influenza or for patients who have been symptomatic for more than 48 hours. Additionally, the safety of Xofluza in pregnant and breastfeeding women has not been established. Patients should report any adverse reactions to their healthcare provider and follow recommended dosage guidelines to ensure optimal medication efficacy and management of side effects.
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