Buy Pemnat : Pemetrexed 500 Mg Injection Online


Brand Name: Pemnat
Composition: Pemetrexed
Strength: 500 mg
Form: Injection
Packaging: Pack of 1 Vial
Manufactured by: Natco Pharma Ltd.
Prescription Requirement: *Yes*



Pemnat is a brand name for the drug Pemetrexed, which belongs to the group of chemotherapy medicines used to treat cancer patients. It is a sterile, non-pyrogenic, clear, and colorless solution for injection, available in vials.


Each vial of Pemnat contains Pemetrexed disodium equivalent to 500 mg of Pemetrexed as the active ingredient, along with mannitol (50 mg), sodium hydroxide, and hydrochloric acid (to adjust the pH).


Pemnat is primarily used for the treatment of malignant pleural mesothelioma, a type of cancer that affects the lining of the lungs. It is also indicated for the treatment of locally advanced or metastatic non-small cell lung cancer that has not been treated previously.

Usage and Dosage:

Pemnat should be administered only under the supervision of a qualified healthcare professional who is well-versed in the use of chemotherapy drugs. The recommended dosage typically depends on the patient’s body weight, medical history, and other relevant factors.

The recommended dose of Pemnat for mesothelioma is 500 mg/m2 body surface area administered as an intravenous infusion over 10 minutes on Day 1 of a 21-day cycle, along with vitamin B12 and folic acid supplementation. The treatment may continue for up to 6 cycles.

For non-small cell lung cancer, the recommended dose is 500 mg/m2 administered on Day 1 of each 21-day cycle, along with vitamin B12 and folic acid supplementation. The treatment may continue until disease progression or unacceptable toxicity occurs.

Storage Conditions:

Pemnat should be stored at 2-8°C (36-46°F) in its original container until use. Prolonged exposure to light should be avoided. If stored at room temperature (≤25°C) for up to 24 hours before use, the vial should be protected from light.

Mechanism of Action:

Pemnat exhibits its anti-cancer activity by inhibiting certain critical enzymes responsible for the replication and repair of DNA in cells. Specifically, it inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase, thereby blocking the synthesis of new DNA and RNA molecules necessary for cancer cell growth and division.


Pemnat is contraindicated in patients with a history of severe hypersensitivity reactions to Pemetrexed or any other component of the formulation. It should not be used in pregnant or breastfeeding women, as it may cause harm to the fetus or newborn.


Pemnat may interact with other medicines and supplements and cause adverse effects. Therefore, patients must inform their doctor if they are taking any prescription or over-the-counter medicines, herbal remedies, or dietary supplements before starting treatment with Pemnat.

Adverse Reactions:

The common side effects observed with Pemnat are fatigue, nausea, vomiting, loss of appetite, low white blood cell count, low platelet count, anemia, fever, constipation, diarrhea, mouth sores, skin rash, and injection site reactions. Serious side effects such as severe bone marrow suppression, kidney toxicity, liver injury, lung problems, and severe allergic reactions can also occur, but they are rare.

In conclusion, Pemnat is a potent chemotherapy drug used to treat mesothelioma and non-small cell lung cancer. It should be used only under the supervision of a doctor and following their prescribed dosage. Patients should be monitored closely for side effects and report them to their healthcare provider immediately.


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