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Perjeta is a monoclonal antibody used in the treatment of HER2-positive breast cancer. It works by preventing the HER2 receptor from interacting with other receptors. It belongs to the class of drugs known as HER2 inhibitors and is FDA approved to be used in combination with Herceptin and chemotherapy. Perjeta has been shown to significantly improve progression-free survival in patients with metastatic HER2-positive breast cancer. It is administered intravenously once every three weeks and can be continued up to a year or more in certain patients who are responding well to treatment. Common side effects of Perjeta include fatigue, nausea, diarrhea, and hair loss.
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Tagrisso (osimertinib) is a targeted cancer therapy designed for treating non-small cell lung cancer (NSCLC) with specific mutations. It works by inhibiting the activity of the EGFR protein that promotes cancer cells’ growth and survival. Clinical trials proved that osimertinib is highly effective in treating advanced NSCLC patients, particularly those with the T790M mutation. A phase 3 trial found that osimertinib was significantly more effective and better-tolerated than chemotherapy at prolonging progression-free survival. Besides, Tagrisso has been studied in combination with other cancer therapies, indicating even better outcomes for advanced NSCLC patients. Its targeted mechanism and high efficacy make it a valuable option for treating this type of cancer.